Diving through Membranes: Molecular Cunning to Enforce the Endosomal Escape of Antibody-Targeted Anti-Tumor Toxins

Membranes are vital barriers by which cells control the flux of molecules and energy between their exterior and interior and also between their various intracellular compartments.While numerous transport systems exist for click here ions and small molecules, the cytosolic uptake of larger biological molecules and in particular antibody-targeted dru

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A novel circular intuitionistic fuzzy AHP&VIKOR methodology: An application to a multi-expert supplier evaluation problem

VIKOR method being one of the frequently used Multi-Criteria Decision Making (MCDM) methods, is based on the distances of alternatives to positive and negative ideal solutions, la rams crop top and presents compromising solutions.AHP is another MCDM method dividing the big problem into small and manageable problems through pairwise comparisons of c

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The functional domain of GCS1-based gamete fusion resides in the amino terminus in plant and parasite species.

Fertilization is one of the most important processes in all organisms utilizing sexual reproduction.In a previous study, we succeeded in identifying a novel male gametic transmembrane protein GCS1 (GENERATIVE CELL SPECIFIC 1), also called HAP2 (HAPLESS 2) in the male-sterile Arabidopsis thaliana mutants, as a factor critical to gamete fusion in flo

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